丁延峰 博士

1988-1993年获医学学士学位。于1993-1996和1998-2001年在河北医科大学获取生理学专业硕士、博士学位，导师何瑞荣教授。参与多项国家和省级科学基金的研究。于2003年2月到美国进行博士后研究，侧重于心血管疾病和化学感受器的研究。其间作为主研人获美国心脏协会资助的博士后研究基金；并参与数项美国健康研究所资助和美国心脏协会资助的科研项目。现在新乡医学院任生理学教授，专长心血管生理及其神经调控。

B. 学习和工作经历

1988.9---1993.7河南省新乡医学院 临床医学系学生

1993.9---1996.7河北医科大学 生理学硕士研究生　导师：何瑞荣教授

1996.9---1998.9 河南省新乡医学院生理学教研室 
1998.9---2001.7 河北医科大学 生理学博士研究生　导师：何瑞荣教授

2001.8---2003.2 河南省新乡医学院生理学教研室

2003.2---2005.7 美国Auburn 大学解剖，生理和药理学系博士后。Supervisor: Zhing, Juming

2005.8---2006.8 美国Nebraska医学中心生理系.博士后 Supervisor: Schultz, Harold D

2006.9---2009.1美国Nebraska医学中心生理系.Research Associate。Chair: Zuck, IvringH

2009.2--- 2010.10美国北德州大学健康研究所生理系。Senior Research Associate

2012.1-- 河南新乡医学院生理和神经生物学教研室.

C. 学术著作

研究论文：

Ding Yanfeng, Li YL, Schultz HD. Role of blood flow in carotid body chemoreflex function in heart failure. J Physiol 2011; 589: 245-258.*Commentary by Fitzgerald RS. “The cardiovascular mighty mini-ruler.” Journal of Physiology, 2011,589:455–456.

Li YL, Zheng H, Ding Yanfeng, Schultz HD. Expression of neuronal nitric oxide synthase in rabbit carotid body glomus cells regulates large-conductance Ca2+-activated potassium currents. J
Neurophysiol 2011; 103:3027-3033.

Ding Yanfeng, Winters A, Ding M, Graham S, Akopova I, Muallem S,et al.Reactive oxygen species-mediated TRPC6 protein activation in vascular myocytes, a mechanism for vasoconstrictor-regulated vascular tone. J Biol Chem. 2011;286:31799-809.

Graham S, Ding M, Ding Yanfeng, Sours-Brothers S, Luchowski R, Gryczynski Z, YorioT, Ma H, Ma R.
Canonical transient receptor potential 6 (TRPC6), a redox-regulated cation channel. J Biol Chem. 2010;285:23466-76.

Yanfeng Ding, Yu-Long Li, Matthew C Zimmerman, Harold D Schultz. Elevated mitochondrial superoxide contributes to enhanced chemoreflex in heart failure rabbits. American Journal of Physiology,
2010, 298(2): R413-421.

Yanfeng Ding, Yu-Long Li, Matthew C Zimmerman, Robin L Davisson, Harold D Schultz. Role of CuZn Superoxide Dismutase on Carotid Body Function in Heart Failure Rabbits. Cardiovascular
Research, 2009; 81(4):678-685.

Yulong Li, Yanfeng Ding, Chad Agnew, Harold D. Schultz.Exercise training improves peripheral chemoreflex function in heart failure rabbits. Journal of Applied Physiology, 2008;105(3):782-90.

Yanfeng Ding, Yulong Li, Harold D. Schultz. Downregulation of carbon monoxide as well as nitric oxide contributes to peripheral chemoreflex hypersensitivity in heart failure rabbits. Journal of
Applied Physiology, 2008;105(1):14-23.

Yanfeng Ding, Gregory L Brower, Qiao Zhong, David Murray, Merrilee Hollan, Joseph S Janicki, Juming Zhong. Defective intracellular Ca2+ homeostasis contributes to myocyte dysfunction during ventricular remodeling induced by chronic volum overload in rats. Clinical and Experimental Pharmacology and Physiology, 2008, 35:827-835.

Harold D. Schultz, Yulong Li,Yanfeng Ding. Arterial chemoreceptors and sympathetic nerve activity: implications for hypertension and heart failure.Hypertension, 2007, 50: 6-13.

Yanfeng Ding, Ruijiao Zou, Robert L Judd, Juming Zhong. Endothelin-1 receptor blockade prevented the electrophysiological dysfunction in cardic myocyte of streptozotocin-induced diabetic rats. Endocrine, 2006, 30: 121-127.

Yanfeng Ding, Ruijiao Zou, Robert L Judd, Juming Zhong. Effects of Gender difference on cardic myocyte dysfunction in streptozotocin-induced diabetic rats. Endocrine, 2006, 29: 135-141.

赵红岗, 李文斌,刘惠卿 ,冯荣芳,丁延峰,范明. 肢体缺血预处理诱导大鼠缺血再灌注海马HSP70表达. 中华老年心脑血管病杂志.2006,8(6): 416-419.

Yanfeng Ding, Zou Ruijiao, Robert L Judd, Dean D. Schwartz, Juming Zhong. Contribution of endothelin-1 in cardiac myocyte dysfunction in Type-1 diabetic rats. Journal of Cardiothoracic-Renal Research, 2006,1:23-30.

Shi-Sheng Zhou, Jun Yang, Yao-Qin Li, Lin-Yan Zhao, Ming Xu and Yanfeng Ding. Effect of Cl- channel blockers on aconitine-induced arrhythmias in rat heart. Experimental Physiology, 2005, 90:
865-872.

Yanfeng Ding, Dean Schwartz, Philip Posner, Juming Zhong. Hypotonic swelling stimulates L-type Ca2+ channel activity in vascular smooth muscle cells through PKC. American Journal of Physiology, 2004,
287: C413-421.

Shisheng Zhou, Zhan Gao, Ling Dong, Yanfeng Ding, Xiaodong Zhang, Yuemin Wang, Jianming Pei, Feng Gao, Xinliang Ma. Anion channels influence excitation-contraction coupling by modulating L-type Ca2+ channel in ventricular myocytes. Journal of Applied Physiology. 2002,93(5):1660-1668.

丁延峰,李东亮，何瑞荣。非心脏缺血性预处理的心肌保护作用。 国外医学(生理,病理科学和临床分册). 2002, 22(2): 142-144. (综述).

赵国安,丁延峰,牛新清,李东亮,何瑞荣. 心脏和肾脏短暂缺血对心肌保护作用的比较研究。中华心血管病杂志,2002, 30(7):424-427.

李东亮, 赵宏岗,王东霞,丁延峰. 孕酮对缺血/再灌注大鼠脑皮层水肿的影响. 中国应用生理学杂.2002,17(4):327-329.

 

参编教材

《医学生理学》（副主编） 军事谊文出版社 2003

 

D近年来的参研项目

血管紧张素 II受体1和2再缺血性心衰所致外周化学感受器活动增强中的作用。国家自然基金委资助, No 3007028. 主申请人。20011.1-2013.12

Chemoreflex function in heart failure in “Neuro-circulatory function chronic heart disease, 美国国家健康研究所资助重大课题组（Principal Project Group, PPG）5P01HL062222-09”. 主要参与人。. 7/1999-6/2014

Reduced blood flow in carotid arteries is a trigger contributing to peripheral chemoreflex hypersensitivity in chronic heart failure rabbits? 美国心脏组织资助的博士后研究基金（Postdoctoral fellowship from the American Heart Association, Heartland Affiliate）主申请人. No. 0725749Z. 7/2007-6/2009

The role of G-protein βγ subunits in the β-adrenenergic modulation of cardiac L-type calcium channels.美国心脏组织资助(American Heart Association) 1/2002--12/2004, No.0255030B, 主要完成人.

肾脏缺血预处理心脏保护的神经机制. 国家自然基金委资助, No 3007028. 主要参与人。2001.1-2004.12

肢体缺血预处理心脏保护作用及其分子机制。河南省科技厅杰出青年科学基金。主申请人。2003.1—2005.12, No 200300024.

小肠缺血预处理的脑保护作用。河南省教育厅杰出青年教师基金, 主申请人