个人简介
梁真真，女，博士研究生学历，讲师。主持一项国家 自然科学基金青年基金，以第一作者累计发表 SCI 论文 6 篇。
联系方式
电话：17757729260
邮箱：221010@xxmu.edu.cn
研究方向
辐射肿瘤学
招生方向
生物医学工程（0831）
教育经历
2010/09-2015/06，新乡医学院，预防医学，医学学士
2015/09-2018/06，吉林大学，流行病与卫生统计学，医学硕士
2018/09-2022/06，吉林大学，放射医学，医学博士
工作经历
2022/07 至今，新乡医学院，流行病与卫生统计学教研室，讲师
承担项目
1. PRMT5选择性剪接异构体通过甲基化PDCD4调控肝癌辐射敏感性的机制研究，国家自然科学基金，2024.01- 2026.12，30 万元，主持人。
参与科研项目：
1、数字诊疗辐射生物效应及其评估新技术研究-光子放疗生物学效应评估技术研究（国家重点研发计划）
2、蛋白质精氨酸甲基转移酶5的选择性剪切子PRMT5S在辐射损伤及细胞死亡中的作用及调控机制（国自然面上项目）
3、立体定向放疗（伽玛刀）多中心临床评价及大数据研究 （省级项目）
4、长春市九台区、双阳区城镇化流动人口结构和享受基本公共服务均等化情况调查 （省级项目）
5、“长吉图开发开放先导区“流动人口生存现状专题调查” （省级项目）
6、呼吸道菌群在PM2.5急性暴露诱发小胶质细胞活化中的作用及机制(省级项目)
7、2022年专创融合特色示范课程（厅级项目）
代表性论文
1. Huang L, Liang Z*, Chen H*. Association between physical activity and frailty transitions in middle-aged and older adults: a nationwide longitudinal study. Int J Behav Nutr Phys Act. 2025 Mar 10;22(1):31. （IF=5.5，并列通讯）
2. Huang L, Jin W, Liang Z*, Chen H*. Associations between depressive symptoms, activity of daily living, and falls/severe falls: evidence from two prospective longitudinal studies. Soc Psychiatry Psychiatr Epidemiol. 2025 May 19. （IF=3.5，并列通讯）
3. Huang L, Liao C, Liang Z*, Chen H*. Associations of metabolic heterogeneity of obesity with depression progression among middle-aged and older adults in China: A prospective study. J Affect Disord. 2025 Dec 1;390:119875. （IF=4.9，并列通讯）
4. Huang L, Chen H, Liang Z*. Enhancing the convenience of frailty index assessment for elderly Chinese people with machine learning methods. Sci Rep. 2024 Oct 5;14(1):23227. （IF：3.9，通讯）
5. Liang Z, Jin W, Huang L, Chen H. Body mass index, waist circumference, hip circumference, abdominal volume index, and cognitive function in older Chinese people: a nationwide study. BMC Geriatr. 2024 Nov 8;24(1):925. （IF：3.8，一作）
6. Liang Z, Jin W, Huang L, Chen H. Association between diverse obesity indicators and sleep quality in elderly Chinese people: a National Study. Front Nutr. 2024 Oct 11;11:1459480. （IF：5.1，一作）
7. Liang Z, Xue C, Chen Q, Li M, Li G, Feng H, Liu Y, Liu X, Ma S. Screening of Prognostic Biomarkers for Stereotactic Body Radiation Therapy in Primary Liver Cancer. Dose Response. 2022 May 6;20(2):15593258221097589. （IF：2.623，一作）
8. Liang Z, Liu L, Wen C, Jiang H, Ye T, Ma S, Liu X. Clinicopathological and Prognostic Significance of PRMT5 in Cancers: A System Review and Meta-Analysis. Cancer Control. 2021 Jan-Dec;28:10732748211050583. （IF：3.302，一作）
9. Liang Z, Wen C, Jiang H, Ma S, Liu X. Protein Arginine Methyltransferase 5 Functions via Interacting Proteins. Front Cell Dev Biol. 2021 Aug 27; 9:725301. （IF：6.684，一作）
10. Liang Z, Xin R, Yu Y, Wang R, Wang C, Liu X. Diagnostic value of urinary survivin as a biomarker for bladder cancer: a systematic review and meta-analysis of published studies. World J Urol. 2018;36(9):1373-1381. （IF：3.217，一作）
11. Liang Z, Zhang Q, Wang C, Shi F, Cao H, Yu Y, Zhang M, Liu X. Hyaluronic Acid/ Hyaluronidase as Biomarkers for Bladder Cancer: a Diagnostic Meta-analysis. Neoplasma. 2017 Sep 12. （IF：1.771，一作）
12. Liang Z, Liu X, Zhang Q, Wang C, Zhao Y. Diagnostic value of microRNAs as biomarkers for cholangiocarcinoma. Dig Liver Dis. 2016 Oct;48(10):1227-32. （IF：3.287，一作）
13. Zhang K, Liang Z#, Wang C, Zhang X, Yu B, Liu X. Diagnostic validity of magnetic resonance parkinsonism index in differentiating patients with progressive supranuclear palsy from patients with Parkinson's disease. Parkinsonism Relat Disord. 2019;66:176-181. （IF：3.926， 并列一作）
14. Liu L, Liang Z, Ma S, Li L, Liu X. Radioprotective countermeasures for radiation injury (Review). Mol Med Rep. 2023 Mar;27(3):66. （IF：3.423，排名第2位）
15. Zhang C, Liang Z, Ma S, Liu X. Radiotherapy and Cytokine Storm: Risk and Mechanism. Front Oncol. 2021 May 20;11:670464.（IF：6.244，排名第2位）
16. Wang R, Liang Z, Liu X. Diagnostic accuracy of optical coherence tomography angiography for choroidal neovascularization: a systematic review and meta-analysis. BMC Ophthalmol. 2019;19(1):162. （IF：1.413，排名第2位）
17. Shi D, Liang Z, Zhang C, Zhang H, Liu X. The effect of surgery on the survival status of patients with locally advanced cervical cancer after radiotherapy/chemoradiotherapy: a meta-analysis. BMC Cancer. 2018;18(1):308. （IF：3.15，排名第2位）
18. Shi F, Liang Z, Zhang Q, Wang C, Liu X. The performance of one-step nucleic acid amplification assay for intraoperative detection of sentinel lymph node macrometastasis in breast cancer: An updated meta-analysis. Breast. 2018;39:39-45. （IF：3.754，排名第2位）
19. Wang C, Liang Z, Liu X, Zhang Q, Li S. The Association between Endometriosis, Tubal Ligation, Hysterectomy and Epithelial Ovarian Cancer: Meta-Analyses. Int J Environ Res Public Health. 2016 Nov 14;13(11). (IF：2.849，排名第2位)
20. Chen Q, Qu S, Liang Z, Liu Y, Chen H, Ma S, Liu X. Cathepsin H Knockdown Reverses Radioresistance of Hepatocellular Carcinoma via Metabolic Switch Followed by Apoptosis. Int J Mol Sci. 2023 Mar 9;24(6):5257. (IF：5.6，排名第3位)
21. Zhang K, Zhao Y, Liang Z, Wang C, Liu X. Validity of the McDonald criteria in predicting second events in multiple sclerosis. Mult Scler Relat Disord. 2020 Aug;43:102223. （IF：4.339，排名第3位）
22. Shi F, Zhang Q, Liang Z, Zhang M, Liu X. One-step nucleic acid amplification assay is an accurate technique for sentinel lymph node biopsy of breast cancer patients: a meta-analysis. Br J Cancer. 2017 Oct 10;117(8):1185-1191. (IF：5.416，排名第3位)
23. Mei F, Fan J, Yuan J, Liang Z, Wang K, Sun J, Guan W, Huang M, Li Y, Zhang WW. Comparison of Venous Thromboembolism Risks Between COVID-19 Pneumonia and Community-Acquired Pneumonia Patients. Arterioscler Thromb Vasc Biol. 2020 Sep;40(9):2332-2337. （IF：8.311，排名第4位）
24. Zhao Y, Zhao Y, Wang C, Liang Z, Liu X. DIAGNOSTIC VALUE OF ANTI-MÜLLERIAN HORMONE AS A BIOMARKER FOR POLYCYSTIC OVARY SYNDROME: A META-ANALYSIS UPDATE. Endocr Pract. 2019 Oct;25(10):1056-1066. (IF：3.443，排名第4位）
25. Zhang C, Yang T, Chen H, Ding X, Chen H, Liang Z, Zhao Y, Ma S, Liu X. METTL3 inhibition promotes radiosensitivity in hepatocellular carcinoma through regulation of SLC7A11 expression. Cell Death Dis. 2025 Jan 11;16(1):9. (IF：9.6，排名第6位）
26. Liu L, Zhang C, Qu S, Liu R, Chen H, Liang Z, Tian Z, Li L, Ma S, Liu X. ESR1 inhibits ionizing radiation-induced ferroptosis in breast cancer cells via the NEDD4L/CD71 pathway. Arch Biochem Biophys. 2022 Aug 15;725:109299. (IF：4.114，排名第6位）
27. Wen C, Tian Z, Li L, Chen T, Chen H, Dai J, Liang Z, Ma S, Liu X. SRSF3 and HNRNPH1 Regulate Radiation-Induced Alternative Splicing of Protein Arginine Methyltransferase 5 in Hepatocellular Carcinoma. Int J Mol Sci. 2022 Nov 27;23(23):14832. (IF：5.6，排名第7位）
28. Ma S, Fu X, Liu L, Liu Y, Feng H, Jiang H, Liu X, Liu R, Liang Z, Li M, Tian Z, Hu B, Bai Y, Liang B, Liu X. Iron-Dependent Autophagic Cell Death Induced by Radiation in MDA-MB-231 Breast Cancer Cells. Front Cell Dev Biol. 2021 Oct 14;9:723801. （IF：6.684，排名第9位）
29. Feng H, Liu Y, Gan Y, Li M, Liu R, Liang Z, Liu L, Li L, Chen H, Li G, Tian Z, Liu X, Ma S. AdipoR1 Regulates Ionizing Radiation-Induced Ferroptosis in HCC cells through Nrf2/xCT Pathway. Oxid Med Cell Longev. 2022 Jun 13;2022:8091464. (排名第6位）
30. Ma Shumei, Liang Zhenzhen, Chen Qiao, Liu Rui, Guo Yutian, Liu Xiaodong. The challenges of precision radiotherapy technology to the traditional theory of radiobiology[J]. 中华放射医学与防护杂志, 2019, 39(8): 563-571.
31. 刘美彤,徐雪晶,綦松玲,梁真真,张倩,刘欣.吉林省流动老年人的健康状况及医疗服务利用情况[J].中国地方病防治杂志,2016,31(05):522-524.
32. 刘美彤,徐雪晶,张倩,梁真真,何晶,鲍红红,刘欣.吉林省就业流动人口健康认知现状及其影响因素分析[J].中国地方病防治杂志,2015,30(06):481-483.
