个人简介
何广杰，男，1971年11月生，博士，教授，硕士研究生导师。河南省法医学会副会长、中国生物物理学会生物微量元素分会委员、河南省法学会司法鉴定学研究会常务理事，新乡市法庭科学证据重点实验室主任，中国化学会和中国生物物理学会科普专家。主要从事智能影像材料的教学科研工作，研究方向为智能影像探针的设计合成及其生物医学应用。获河南省科技进步奖二等奖1项、河南省教育厅科技成果奖二等奖2项。主持完成国家自然科学基金、河南省自然科学基金、河南省科技攻关计划等项目10余项，作为骨干参与科技部国家重点专项1项。多次荣获河南医药大学创新创业优秀导师、优秀硕士学位论文指导教师，指导本科生河南省大学生创新训练项目3项，指导学生参加全国大学生医学创新大赛暨“一带一路”国际竞赛、全国大学生生命科学竞赛等国家级竞赛并获省级及以上奖项4项，指导校级大学生创新创业课题30余人次，已指导硕士生20余名、本科生80余名。近年来以通讯作者发表SCI论文30余篇，国家发明专利3项，作为副主编参与完成《化学污染与环境保护》《一案一说》两部专著。荣获河南省高等学校优秀共产党员、新乡医学院最美教师、河南医药大学教学管理先进个人和研究生先进管理工作者等荣誉。
联系方式：
河南医药大学北校区新教学实验楼15楼C1515
电话：0373-3831363
邮箱：guangjiehe@163.com
研究方向：
智能影像探针的设计合成及其生物医学应用。
招生方向：
生物医学工程（学术型）
医学技术（专业型）
生物与医药（专业型）
教育经历：
2007/03-2010/03：大连理工大学，化工学院，无机化学专业，博士
2003/09-2006/07：河南师范大学，化学与环境科学学院，无机化学专业，硕士
1993/09-1995/07：河南教育学院，化学系，化学教育专业，学士
工作经历：
2026/03-至今：河南医药大学，医学工程学院，教授
2025/06-2026/03：河南医药大学，法医学院，教授
2018/04-2025/06：新乡医学院，法医学院，教授
2014/01-2018/04：新乡医学院，法医学院，副教授
2012/04-2014/01：新乡医学院，基础医学院，副教授
2010/03-2012/04：新乡医学院，基础医学院，讲师
主持的代表性的科研项目：
l 基于四嗪的生物正交近红外发光稀土配合物荧光探针的设计合成及诊疗肺癌研究，242102311019，河南省科技厅，河南省科技攻关项目，2024-01至2025-12；
l 基于生物正交修饰的巨噬细胞载体荧光药物及诊疗抑郁症研究，XTkf04，精神心理疾病防治河南省协同创新中心开放课题，2024-01至2025-12；
l 二硫键偶联的近红外二区荧光染料、药物复合体系的构建及靶向检测治疗肺癌研究，182300410309，河南省科技厅，河南省自然科学基金项目，2018-01至2019-12；
l 近红外二区荧光染料敏化的硫化铜纳米探针的制备及检测前列腺癌研究，182102310648，河南省科技厅，河南省科技攻关项目，2018-01至2019-12；
l 近红外二区荧光染料敏化的稀土上转换发光纳米材料的制备及其检测肿瘤应用，18A150044，河南省教育厅，河南省高等学校重点科研项目，2018-01至2019-12；
l 基于四嗪生物正交反应的近红外二区激活型荧光探针的制备及肺癌诊疗研究，GG2020010，新乡市科技局，新乡市科技攻关计划项目，2021-01至2022-12；
l 去甲肾上腺素荧光探针的设计合成及其在抑郁症信号传导机制中的应用，ZDSYS2020007，河南省生物精神病学重点实验室开放课题，2021-06至2024-05；
l 三重态-三重态湮灭上转换发光探针的设计合成及在体成像检测肿瘤研究，21371148，国家自然科学基金委员会，国家自然科学基金，2014-01至2015-12。
近五年代表性论文
1. Na Gao#, Yajuan Zhao#, Yuhan Huang, Yanke Zhou, Linlin Yang, Liguo Ji, Hao Zhu, Wenjie Ren*, Guangjie He*. Engineering carbon dots with amplified peroxidase-mimetic activity for dual-modal colorimetric-photothermal sensing of organophosphorus and carbamate pesticides. Analytica Chimica Acta. 2026, 536, 345617.
2. Linlin Yang#, Guangnian Wang#, Fei Xin, Fan Xie, Chenhan Wang, Shaoli Cui, Lili Li*, Guangjie He*, Wenjie Ren*. A novel borondifluoro indolenine-functionalized red-shift ratiometric fluorescent probe for detection of hypochlorous acid in drug-induced liver injury. Talanta. 2027, 311, 130225.
3. Shaoli Cui#, Fengxiang Liu#, Tianli Zhang, Binghui Du, Guangnian Wang, Jiarui Lu, Di Han, Taigang Liu, Meiting Wang, Guangjie He*, Yongtao Xu*. The influence of a type I antifreeze protein and its mutants on methane hydrate adsorption-inhibition: A molecular dynamics simulation study. J. Chem. Phys. 2026, 164, 194501.
4. Na Gao#, Yajuan Zhao#, Mengyao Jing, Zhirui Li, Honglei Wang, Xiaolong Hao, Jing Li, Shaoli Cui, Linlin Yang, Liguo Ji, Xiao-Dong Yang, Jing-Yuan Niu*, Guangjie He*. Tailored carbon dots with photoresponsive oxidase-mimicking activity for bacteria-infected wound therapy. Materials Today. 2026, 115396.
5. Yanbei Xi#, Shiqiong Bai#, Fei Xin, Yituan Jin, Fan Xie, Yunfei Wang, Wanbing Shang, Wenqiang Li, Lili Li*, Guangjie He*, Linlin Yang*. A dual-channel fluorescent probe for monitoring NO and Cys changes correlation of ferroptosis in depression cell model. Talanta. 2026, 301, 129351.
6. Lu Yang#, Huan Li#, Miaomiao Li, Aoxiang Fu, Shiqiong Bai, Jing Li, Linlin Yang *, Guangjie He*. Preparation of a Near-infrared Probe Based on Triphenylamine Thiophene and its Use for the Fluorescence Imaging of H₂S in Living Cells. J. Fluoresc. 2026, 1921-1928.
7. Linlin Yang#, Shiqiong Bai#, Yuqing Nie, Yixuan Li, Fei Xin, Panpan Song, Na Gao, Liguo Ji, Lili Li*, Guangjie He*. Bioorthogonally activatable methylene blue platform for selective prodrug activation and fluorescent imaging in living systems. Analytica Chimica Acta. 2026, 1384, 344988.
8. Shaoli Cui#, Fengxiang Liu#, Panpan Song, Jiarui Lu, Di Han, Taigang Liu, Meiting Wang, Yiyang Song, Guangjie He*, Yongtao Xu*, Distinct mechanisms of methane hydrate growth inhibition by ice-binding and non-ice-binding sites in a hyperactive insect antifreeze protein, Results in Engineering. 2025, 28, 107721.
9. Liguo Ji#, Aoxiang Fu#, Yuying Zhang, Ying Xu, Yanbei Xi, Shaoli Cui, Na Gao, Linlin Yang, Wanbing Shang, Zhijun Yang, Guangjie He*. An AIE-TICT fluorescence probe cascade responsive to H₂S polarity and viscosity to track microenvironment changes in cellular model of ischemia-reperfusion injury. Analytica Chimica Acta. 2025, 1334, 343425.
10. Jinhe Xu#, Huan Chen#, Yuekai Wang, Danni Yin, Hongli Li*, Linlin Yang*, Guangjie He*. A new benzil-based chemosensor for colorimetric and fluorometric detection of Cu2+ with high selectivity and sensitivity in living cells. Journal of Molecular Structure. 2026, 1424, 139489.
11. Yanbei Xi, Shiqiong Bai, Yuan Tian, Yanan Lv, Liguo Ji, Wenqiang Li*, Guangjie He*, Linlin Yang*. Golgi-targeted NIR fluorescent probe with large stokes shift for real-time monitoring of nitric oxide in depression model. Bioorganic Chemistry. 2024, 148, 107476.
12. Shaoli Cui#, Te Kong#, Jiahao Wang, Zhihao Gao, Aoxiang Fu, Yanbei Xi, Liguo Ji, Na Gao, Linlin Yang*, Guangjie He*. An AIE enhanced fluorescence probe based on the "rotor" structure to detect level 3 structure of latent fingerprints. Dyes and Pigments. 2024, 229, 112040.
13. Liguo Ji#, Aoxiang Fu#, Chenxu Liu, Yanbei Xi, Shaoli Cui, Na Gao, Linlin Yang, Wanbing Shang, Nana Ma*, Guangjie He*, Zhijun Yang*. A novel lysosomal targeted near-infrared probe for ratio detection of carbon monoxide in cells and in vivo. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2024, 311, 123987.
14. Linlin Yang#, Pengli Gu#, Aoxiang Fu, Yanbei Xi, Shaoli Cui, Liguo Ji, Lili Li*, Nana Ma, Qingzhi Wang*, Guangjie He*. TPE-based fluorescent probe for dual channel imaging of pH/viscosity and selective visualization of cancer cells and tissues. Talanta. 2023, 265, 124862.
15. Pengli Gu, Lili Li, Aoxiang Fu, Huina Song, Bin Zhao, Lai Wei, Liguo Ji, Wenqiang Li*, Ruiling Zhang, Qingzhi Wang,Guangjie He*, Linlin Yang*. High-performance fluorescence probe for fast and specific visualization of norepinephrine in vivo and depression-like mice. Bioorganic Chemistry. 2023, 131: 106306.
16. Liguo Ji*, Yutian Fu, Nan Yang, Meifei Wang, Linlin Yang, Qingzhi Wang, Wanbing Shang*, Guangjie He*, A fluorescence "turn-on" probe for Cu(II) based on flavonoid intermediates generated by copper-induced oxidative cyclization and its fluorescence imaging in living cells, Analytical Biochemistry,2022 ,655, 114855.
17. Linlin Yang#, Pengli Gu#, Beining Li, Junwan Li, Aoxiang Fu, Xianyu Gong, Yanmei Huang, Lixia Xie, Liguo Ji, Nana Ma*, Lili Li*, Guangjie He*. A homocysteine-selective fluorescent probe for cell imaging based on substitution-rearrangement process. Dyes and Pigments. 2022, 207: 110802.
18. Linlin Yang#, Nan Yang#, Pengli Gu, Yihua Zhang, Xianyu Gong, Shichao Zhang, Junwan Li, Liguo Ji*, Guangjie He*. A novel naphthalimide-based fluorescent probe for the colorimetric and ratiometric detection of SO2 derivatives in biological imaging. Bioorganic Chemistry. 2022,123, 105801.
19. Linlin Yang*, Nan Yang, Pengli Gu, Chuang Wang, Beining Li, Yihua Zhang, Liguo Ji, Guangjie He*. A novel flavone-based ESIPT ratiometric fluorescent probe for selective sensing and imaging of hydrogen polysulfides. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2022, 271: 120962.
20. Yaoyun Hu#, Zhuye Shang#, Pengli Gu#, Guangjie He*, Run Zhang*, Qingtao Meng*, Zhiqiang Zhang*. A Red-Emission Fluorescence Probe Based on 1,4-Addition Reaction Mechanism for the Detection of Biothiols in Vitro and in Vivo. Chemistry Letters. 2022, 51, 1102-1106.
21. Jianhua Liu#, Haoyuan Yin#, Zhuye Shang#, Pengli Gu, Guangjie He*, Qingtao Meng*, Run Zhang*, Zhiqiang Zhang*. Sequential detection of hypochlorous acid and sulfur dioxide derivatives by a red-emitting fluorescent probe and bioimaging applications in vitro and in vivo. RSC Advances. 2022, 12, 15861-15869.
获批专利
1.何广杰，李静，杨璐等. 一种基于香豆酰肼的硫醇荧光探针的制备方法及应用，专利号：ZL 2016 1 0052048.6，2020-07-07，授权。
2.何广杰，杨林林，倪天军等. 一种基于香豆素铜离子配合物的荧光探针，制备方法及其在选择性识别焦磷酸盐中的应用，专利号：ZL 2017 1 0937514.3，2020-12-15，授权。
3.何广杰，毛光兰，王中权等. 一种基于香豆素席夫碱铜离子配合物硫醇荧光探针及其制备方法和应用，专利号：ZL 2016 1 0030550.7，2019-06-21，授权。
重要科技奖项
1.高生物安全性医用材料在肿瘤及病原体诊疗防控中的关键技术与应用，河南省人民政府，河南省科学技术进步奖二等奖，2026.02，第八。
2.小分子荧光探针的设计合成及肿瘤靶向诊疗应用，河南省教育厅，科技成果奖二等奖，2024.06，第一。
3.荧光探针的设计合成及其生物医学成像诊疗应用，河南省教育厅，科技成果奖二等奖，2026.05，第一。
