个人信息
职 称：教授
邮 箱：hnpdsyyl@163.com
人才称号:河南省杰青，省教育厅学术技术带头人
行政职务：生理与病理学系主任
学历学位：博士研究生
毕业院校：华中科技大学
从事专业及研究方向
• 生理学，神经生理
• 病理生理学，心脑血管衰老与血管性痴呆，神经退行性病变
参加项目（按时间倒叙排列）
• 国家自然科学基金委员会, 面上项目, 82271460, TRPM2/CREB介导的硫化氢合成酶抑制在阿尔茨海默病神经退变中的作用及机制研究, 2023-01-01 至 2026-12-31, 51万元, 在研, 主持
• 国家自然科学基金委员会, 联合基金项目, U1804197, Tau蛋白异常聚集激活钙神经素诱导阿尔兹海默病记忆障碍的神经网络钙振荡机制研究, 2019-01-01 至 2021-12-31, 48万元, 结题, 主持
• 河南省科技厅, 河南省自然科学基金优秀青年基金, 202300410308, 枸杞有效多糖组分预防老年痴呆记忆障碍的机制研究, 2021-01 至 2023-12, 25万元, 结题, 主持
• 河南省教育厅河南省科技创新人才支持计划，18HASTIT047，钙振荡对Tau蛋白过度聚集的海马神经网络突触可塑性的影响及其机制，2019-01至2020-12，30万，结题，主持
• 国家自然科学基金，青年基金项目，81200836，LBP-Ⅲ抑制有机磷所致血管性痴呆的作用机制研究，2013-01至2015-12，23万，结项，主持
代表性成果（按时间倒叙排列）
• Niu Q, Li D, Zhang J, Piao Z, Xu B, Xi Y, Mohamed Kamal NNSN*, Lim V*, Li P*, Yin Y*.The new perspective of Alzheimer's Disease Research: Mechanism and therapeutic strategy of neuronal senescence. Ageing Res Rev. 2024 Dec;102:102593. (IF=12.5)
• Zuo Y, Liu HT, Lin LB, Yue RZ, Liu HH, Wang HW, Wang L, Hou RL, Liu WZ, Li CZ, Wang JZ, Li P, Yin YL*. A new metal ion chelator attenuates human tau accumulation-induced neurodegeneration and memory deficits in mice.Exp Neurol. 2024 Mar;373:114657. (IF=5.3)
• Yin Y, Wei L, Caseley EA, Lopez-Charcas O, Wei Y, Li D, Muench SP, Roger S, Wang L, Jiang LH. Leveraging the ATP-P2X7 receptor signalling axis to alleviate traumatic CNS damage and related complications. Med Res Rev. 2023 Mar 16. (IF=12.388)
• Yin YL, Chen Y, Ren F, Wang L, Zhu ML, Lu JX, Wang QQ, Lu CB, Liu C, Bai YP, Wang SX*, Wang JZ*, Li P*. Nitrosative stress induced by homocysteine thiolactone drives vascular cognitive impairments via GTP cyclohydrolase 1 S-nitrosylation in vivo [J]. Redox Biology, 2022, 102540. (IF=10.787)
• Yin YL#, Wang HH#, Gui ZC, Mi S, Guo S, Wang Y, Wang QQ, Yue RZ, Lin LB, Fan JX, Zhang X, Mao BY, Liu TH, Wan GR, Zhan HQ, Zhu ML, Jiang LH*, Li P*. Citronellal Attenuates Oxidative Stress-Induced Mitochondrial Damage through TRPM2/NHE1 Pathway and Effectively Inhibits Endothelial Dysfunction in Type 2 Diabetes Mellitus [J]. Antioxidants, 2022,11:2241. (IF=7.675)
• Qiu Y, Chao CY, Jiang L, Zhang J, Niu QQ, Guo YQ, Song YT, Li P*, Zhu ML*, Yin YL*. Citronellal alleviate macro- and micro-vascular damage in high fat diet / streptozotocin - Induced diabetic rats via a S1P/S1P1 dependent signaling pathway. European Journal of Pharmacology,920(2022) 174796. (IF=5.195.)
• Yin YL, Liu YH, Zhu ML, Wang HH, Qiu Y, Wan GR, Li P*. Floralozone improves cognitive impairment in vascular dementia rats via regulation of TRPM2 and NMDAR signaling pathway. Physiol Behav.2022 Mar8;249:113777. (IF=3.244)
• Yin Y, Niu Q, Hou H, Que H, Mi S, Yang J, Li Z, Wang H, Yu Y, Zhu M, Zhan H, Wang Q*, Li P*. PAE ameliorates doxorubicin-induced cardiotoxicity via suppressing NHE1 phosphorylation and stimulating PI3K/AKT phosphorylation. International Immunopharmacology 113 (2022) 109274. (IF=5.714)
• Qiu Y, Xue XJ, Liu G, Shen MM, Chao CY, Zhang J, Guo YQ, Niu QQ, Yu YN, Song YT, Wang HH, Wang SX, Chen YJ, Jiang LH*, Li P*, Yin YL*. Perillaldehyde improves cognitive function in vivo and in vitro by inhibiting neuronal damage via blocking TRPM2/NMDAR pathway [J]. Chin Med. 2021 Dec 13;16(1):136. (IF=5.455)
• Ye J, Yin Y*, Liu H, Fang L, Tao X, Wei L, Zuo Y, Yin Y, Ke D, Wang JZ*. Tau inhibits PKA by nuclear proteasome-dependent PKAR2alpha elevation with suppressed CREB/GluA1 phosphorylation. Aging Cell. 2020 Jan;19(1): e13055. (IF=9.304)
• Yin Y, Gao D, Wang Y et al.Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling. Proc Natl Acad Sci U S A. 2016, Jun 28;113(26):E3773-81. (IF=9.463)
• 河南省科技进步奖，2019，三等奖，LBP-Ⅲ抑制有机磷所致的血管性痴呆的作用机制研究，尹雅玲等.
• 治疗阿尔海默式综合症的药物组合物及其应用，国家发明专利，ZL201410033123.5，尹雅玲等.
