个人信息
职 称：特聘教授
邮 箱：jianglinhua@xxmu.edu.cn
人才称号：科技部高端外国专家、中原英才创新人才
行政职务：基础医学院学术副院长
学历学位：博士研究生
毕业院校：利兹大学
从事专业及研究方向
• 研究离子通道神经退变性疾病和脑损伤发生、中枢神经系统功能修复和再生中的作用机制，以及研发靶向离子通道药物。
参加项目（按时间倒叙排列）
• 河南省中原英才计划-创新人才项目 2025
• 河南省神经修复与蛋白修饰重点实验室(学术带头人) 2025
• 国家自然科学基金面上项目：TRPM2通道介导阿尔兹海默病神经元氧化损伤的作用机制及靶向干预研究（82371421），2024.01-2027.12，49万元，主持
• 国家科技部国家高端外国专家引进计划项目：老年痴呆神经退变的离子通道机理和药物干预研究（G2022026006L），2022.01-2023.12，40万元，参与
• 河南省高端外国专家引进计划项目：脑损伤的离子通道机制和药物干预研究（HNGD2022067），2022.01-2022.12，14万元，参与
• 国家自然科学基金面上项目：TRPM2通道结构与功能及其与新型通道阻断剂相互作用的研究（C110307），2015.01-2018.12，86万元，主持
代表性成果（按时间倒叙排列）
• Insights into the role of the mechanosensitive Piezo1 channel and signaling mechanisms in CNS functions and diseases. Neuroscience & Biobehavioral Reviews 14:106562. Zhang M, … Ren F* and Jiang L-H* (2026) (中科院1区)
• Stiff matrix promotes lung cancer cell migration through down-regulating the Piezo1 channel expression to facilitate Ca2+-dependent filopodia formation. Materials Today Bio 37: 102786. Jia X, …, Jiang L-H*, Fan Y* and Liu H* (2026) (中科院1区)
• Stiff matrix drives microglial cell migration through Piezo1/Ca2+ /AKT/cofilin signaling axis to regulate F-actin reassembly. Regenerative Biomaterials 13: rbaf124. Chen X, …, Jiang L-H* and Jia X* (2026) (中科院1区)
• The DRN-VLO pathway via distinct 5-HT synaptic mechanisms modulates neuropathic pain–induced depressive-like behaviors in mice. Journal of Headache and Pain 26: 168. Sheng HY*, … and Jiang L-H* (2026) (中科院1区)
• The PKC/NOX/ROS and PYK2/MEK/ERK/PARP signalling pathways drive TRPM2 channel activation induced by non-cytolytic oxidative stress in microglial cells. Redox Report 30: 2503131. Syed Mortadza SA, Zahir NZM, Wei CT and Jiang L-H* (2025) (中科院2区)
• Leveraging the ATP-P2X7 receptor signalling axis to alleviate traumatic CNS damage and related complications. Medicinal Research Reviews 43:1346-1373. Yin Y, …, Wang L* and Jiang L-H* (2023) (中科院1区)
• Piezo1 channel-mediated Ca2+ signalling inhibits LPS-induced activation of the NF-κB inflammatory signalling pathway and generation of TNF-α and IL-6 in microglial cells. Glia 71:848-865. Malko P, Jia XL, Wood I and Jiang L-H* (2022) (中科院2区)
• P2X4 receptor promotes mammary cancer progression by sustaining autophagy and associated mesenchymal transition. Oncogene 41:2920-2931. Chadet S, ...., Jiang L-H, Murrell-Lagnado R and Roger S (2022) (中科院1区)
• Reactive oxygen species-induced TRPM2-mediated Ca2+ signalling in endothelial cells. Antioxidants 10:718. Ding R, Yin Y and Jiang L-H* (2021) (中科院2区)
• TRPM2 channel-mediated cell death: an important mechanism linking oxidative stress-inducing pathological factors to associated pathological conditions. Redox Biology 37:101755. Malko P and Jiang L-H* (2020) (中科院1区)
• The TRPM2 channel nexus from oxidative damage to Alzheimer’s pathologies: an emerging novel intervention target for age-related dementia. Aging Research Review 47:67-79. Jiang L-H*, Li X, Syed Mortadza SA, Lovatt M and Yang W (2018) (中科院1区)
• ATP-activated P2X7 receptor in the pathophysiology of mood disorders and as an emerging target for the development of novel antidepressant therapeutics. Neuroscience & Biobehavioral Reviews 87:192-205. Wei L, Syed Mortadza SA, …, Roger R and Jiang L-H* (2018) (中科院1区)
• A critical role of TRPM2 channel in Aβ42-induced microglial activation and generation of tumour necrosis factor-α. Glia 66:562-575. Syed Mortadza SA, Sim JA, Neubrand VE and Jiang L-H* (2018) (中科院2区)
• Multiple molecular mechanisms form a positive feedback loop driving amyloid β42 peptide-induced neurotoxicity via activation of the TRPM2 channel in hippocampal neurons. Cell Death & Disease 9:195. Li X and Jiang L-H* (2018) (中科院1区)
• Nitration of TRPM2 as a molecular switch induces autophagy during brain pericyte injury. Antioxidants and Redox Signaling 27:1297-1316. Jiang Q, ..., Jiang L-H*, Yang W* and Han F* (2017) (中科院2区)
