个人信息
职 称：副教授
邮 箱：081053@xxmu.edu.cn
人才称号：教育厅学术技术带头人、教育厅高校青年骨干教师
行政职务：临床药学院院长
学历学位：博士研究生
毕业院校：中国科学院
从事专业及研究方向
• 神经损伤机制研究
参加项目（按时间倒叙排列）
• 河南省科技厅，河南省科技攻关项目-RNF213 功能及变异与烟雾病发病机制， 2022.1-2023.12，主持
• 河南省神经修复重点实验室开放课题，HNSJXF-2018-002，RNF213基因多态性与烟雾病发病机制，2018/09-2020/12, 主持
• 河南省自然科学基金，162300410218，GABAcR-视网膜兴奋毒性损伤及药物干预的靶标，2017/01-2019/12, 主持
• 河南省教育厅，2015年度河南省高校骨干教师支持计划，2015GGJS-132, GABAc受体与视神经损伤，2016/01-2018/12，主持
• 河南省神经修复重点实验室开放课题，HNSJXF-2016-005，视网膜兴奋毒性损伤中螺内酯与GABA受体的作用，2016/09-2018/12,主持
• 新乡医学院精神神经医学学科群开放课题,2016PN-KFKT-07，神经节损伤干预的药物新靶:γ-氨基丁酸受体,2017/1-2019/12,主持
• 国家自然科学基金项目，81100912，孕酮对缺血再灌注脑损伤大鼠TASK基因表达及功能的调节，2012/01-2014/12，主持
代表性成果（按时间倒叙排列）
• Xing Guo # , Ruizhu Yue # , Zhenwu Cui, Shuying Wang, Tian Jia, Wenqiang Li, Wei Zhang, Linlin Shan*, Chaokun Li*.Advances of therapeutic strategies for Alzheimer's disease. J Neurol. 2025;272(10):705.
• Rui-Zhu Yue # , Xing Guo # , Wenqiang Li , Chaokun Li* , Linlin Shan*. HDAC7 knockout mitigates astrocyte reactivity and neuroinflammation via the IRF3/cGAS/STING signaling pathway. Front Cell Neurosci. 2025:19:1683595.
• Guomin Shen#, Chaokun Li# , Qing Cao, Abhin Kumar Megta, Shuang Li, Meng Gao, Hongli Liu, Yan Shen, Yixiang Chen, Haichuan Yu, Sanqiang Li, Weikai Li*. Structural features determining the vitamin K epoxide reduction activity in the VKOR family of membrane oxidoreductases. FEBS J. 2022, 289(15):4564-4579.
• Xinfang An, Zixing Fu,Cendi Mai, Linyu Wei,Dongliang Li, Chaokun Li*, Lin-Hua Jiang*.Increasing the TRPM2 Channel Expression in Human Neuroblastoma SH-SY5Y Cells Augments the Susceptibility to ROS-Induced Cell Death. Cells. 2019,8(1). pii: E28.
• Chaokun Li*, Zixing Fu, Yujie Yang, Jing Yan, Fengtao Liu, Wenhui Zhao, Libin Zhang, Linyu Wei, Zhiwei Feng, Dongliang Li, Lin-Hua Jiang. CRISPR/Cas9-mediated editing of GABRR2 gene in RGC-5 cells induces random exon deletion, exon splicing and new exon recruitment. Biochemical Engineering Journal.2018,139:43-50.
• Jing Yan, Zixing Fu, Libin Zhang, Chaokun Li*. Orai1 is involved in leptin-sensitive cell maturation in mouse dendritic cells.Bioch Bioph Res Com.2018,503:1747-1753.
• Chaokun Li, Li Meng, Li Xin Li, Dongliang Li, Lin-Hua Jiang*, Non-NMDAR neuronal Ca2+-permeable channels in delayed neuronal death and as potential therapeutic targets for ischemic brain damage, Expert Opin Ther Targets, 2015, 19(7): 879-892.
• Chaokun Li*, Linlin Shan, Xinjuan Li, Linyu Wei, Dongliang Li. Mifepristone modulates serotonin transporter function.Neural Regen Res. 2014,9(6):646-52.
• Chaokun Li*, Linyu Wei, Hongbo Jiang, Linlin Shan, Xinjuan Li, Na Lu, Guohong Wang, Dongliang Li. Stable cell line of human SH-SY5Y uniformly expressing TWIK-related acid-sensitive potassium channel and eGFP fusion. Appl Biochem Biotechnol. 2014,172(6):3253-62.
• Xinjuan Li, Hua Han, Ruanling Hou, Linyu Wei, Guohong Wang, Chaokun Li*, Dongliang Li*. Progesterone treatment before experimental hypoxia-ischemia enhances the expression of glucose transporter proteins GLUT1 and GLUT3 in neonatal rats. Neurosci Bull. 2013,29(3):287-94.
• Linlin Shan, Yujie Yang, Jin Wang, Ji Zuo, Xianhong Dong, Chaokun Li*, Dongliang Li.Estradiol inhibits the activity of proton-coupled amino acid transporter PAT1 expressed in Xenopus oocytes. Eur J Pharmacol. 2012,695(1-3):34-9.
• Chaokun Li, Aiyun Wen, Benchang Shen, Jia Lu, Yao Huang, Yongchang Chang*. FastCloning: a highly simplified, purification-free, sequence- and ligation-independent PCR cloning method. BMC Biotechnol. 2011,11:92.
