学术论文

  1. Zhiyuan Niu*, Mengjun Wang, Yangchun Yan, Xinru Jin, Linwei Ning, Bingqian Xu, Yanfeng Wang, Yuekai Hao , Zhixia Luo, Changjiang Guo, Lingtong Zhi, Wuling Zhu*. The Journal of Immunology, 2024, 213 (9): 1318–1328.   [DOI]   [PubMed]   [Journal]
  2. Changjiang Guo*, Meng Dong, Xiang Wang, Jie Yu, Xinru Jin, Shizhuang Cheng, Feiyan Cui, Yifan Qian, Qianqian Bao, Lingtong Zhi, Zhiyuan Niu, Mingfeng Li, Wuling Zhu*. A novel MICA/B-targeted chimeric antigen receptor augments the cytotoxicity of NK cells against tumor cells. Biochemical and Biophysical Research Communications, 2024, 710:149918.   [PubMed]   [Elsevier]
  3. Changjiang Guo#*, Xiali Guo#, Xiaojuan Li, Meng Dong, Xiang Wang, Shizhuang Cheng, Lingtong Zhi, Zhiyuan Niu, Wuling Zhu*. The SpyCatcher-SpyTag interaction mediates tunable anti-tumor cytotoxicity of NK cells. Molecular Immunology, 2024, 165:11-18.   [DOI]   [PubMed]   [Elsevier]
  4. Lingtong Zhi, Xing Wang, Qing Gao, Wenhui He, Chongye Shang, Changjiang Guo a, Zhiyuan Niu, Wuling Zhu*, Xuan Zhang*. Intrinsic and extrinsic factors determining natural killer cell fate: Phenotype and function.Biomedicine & Pharmacotherapy,2023, 165:115136.   [DOI]   [PubMed]   [Elsevier]
  5. Changjiang Guo#*, Han Chen#, Jie Yu, Hui Lu, Qing Xia, Xiaojuan Li, Xiali Guo, Tong Wang, Lingtong Zhi, Zhiyuan Niu, Wuling Zhu*. Engagement of an optimized lentiviral vector enhances the expression and cytotoxicity of CAR in human NK cells. Molecular Immunology, 2023, 155:91-99.   [DOI]   [PubMed]   [Elsevier]
  6. Zhiyuan Niu#*,Zhixia Luo, Pengyang Sun, Linwei Ning, Xinru Jin, Guanxu Chen, Changjiang Guo, Lingtong Zhi, Wei Chang, Wuling Zhu*. In vitro nanobody library construction by using gene designated-region pan-editing technology. BioDesign Research, 2022, 2022:9823578.   [DOI]
  7. Lingtong Zhi#, Meichen Yin#, Xin Su, Zikang Zhang, Hui Lu, Mingfeng Li, Changjiang Guo, Zhiyuan Niu, Xuan Zhang, Wuling Zhu*. A chimeric switch-receptor PD1-DAP10-41BB augments NK92-cell activation and killing for human lung Cancer H1299 Cell. Biochemical and Biophysical Research Communications, 2022, 600(3):94-100.   [DOI]   [PubMed]   [Elsevier]
  8. Lingtong Zhi#, Xin Su, Meichen Yin, Zikang Zhang, Hui Lu, Zhiyuan Niu, Changjiang Guo, Wuling Zhu*, Xuan Zhang*. Genetical engineering for NK and T cell immunotherapy with CRISPR/Cas9 technology: Implications and challenges. Cellular Immunology, 2021, 369:104436.   [DOI]   [PubMed]   [Elsevier]
  9. Zhiyuan Niu#, Guanxu Chen#, Wei Chang, Pengyang Sun, Zhixia Luo, Huiyong Zhang, Lingtong Zhi, Changjiang Guo, Han Chen, Meichen Yin, Wuling Zhu*. Chimeric antigen receptor‐modified macrophages trigger systemic anti‐tumour immunity. The Journal of Pathology, 2021, 253(3):247-257.   [DOI]   [PubMed]   [Wiley]
  10. Huiyong Zhang*#, Wenjiao Xia#, Chen Liang, Xiaoyin Wang, Lingtong Zhi, Changjiang Guo, Zhiyuan Niu, Wuling Zhu*. VEGF165b and its mutant demonstrate immunomodulatory, not merely anti-angiogenic functions, in tumor-bearing mice. Molecular Immunology, 2020, 122:132-140.   [DOI]   [PubMed]   [Elsevier]
  11. Chengui Lu#, Changjiang Guo#, Han Chen, Huiyong Zhang, Lingtong Zhi, Tanyu Lv, Mingfeng Li, Zhiyuan Niu, Ping Lu*, Wuling Zhu*. A novel chimeric PD1-NKG2D-41BB receptor enhances antitumor activity of NK92 cells against human lung cancer H1299 cells by triggering pyroptosis. Molecular Immunology, 2020, 122:200-206.   [DOI]   [PubMed]   [Elsevier]
  12. Mingfeng Li#, Lingtong Zhi#, Meichen Yin, Changjiang Guo, Huiyong Zhang, Chengui Lu, Wuling Zhu*. A novel bispecific chimeric PD1-DAP10/NKG2D receptor augments NK92-cell therapy efficacy for human gastric cancer SGC-7901 cell. Biochemical and Biophysical Research Communications, 2020, 523(3):745-752.   [DOI]   [PubMed]   [Elsevier]
  13. Zhiyuan Niu#, Guanxu Chen#, Han Chen, Meichen Yin, Lingtong Zhi, Wuling Zhu*. Explore the activation efficiency of different ligand carriers on synNotch-based contact-dependent activation system. Turkish Journal of Biochemistry, 2020, 45(6): 817–823.   [DOI]   [De Gruyter]
  14. Changjiang Guo#, Xiaoyin Wang#, Huiyong Zhang, Lingtong Zhi, Tanyu Lv, Mingfeng Li, Chengui Lu, Wuling Zhu*. Structure-based rational design of a novel chimeric PD1-NKG2D receptor for Natural Killer cells. Molecular Immunology, 2019, 114:108-113.   [DOI]   [PubMed]   [Elsevier]
  15. Huiyong Zhang, Enchao Jia, Wenjiao Xia, Tanyu Lv, Chengui Lu, Zhenping Xu, Wuling Zhu*. Utilizing VEGF165b mutant as an effective immunization adjunct to augment antitumor immune response. Vaccine, 2019, 37 (15):2090-2098.   [DOI]   [PubMed]   [Elsevier]
  16. Huiyong Zhang#, Enchao Jia#, Wenjiao Xia, Chengui Lu, Wuling Zhu*. VEGF165b mutant with a prolonged half-life and enhanced anti-tumor potency in a mouse model. Journal of Biotechnology, 2018, 284:84–90.   [DOI]   [PubMed]   [Elsevier]
  17. 张会勇,贾恩朝,夏文娇,路臣桂,朱武凌*. 重组人血管内皮细胞因子VEGF183刺激HUVEC体外增殖. 基因组学与应用生物学,2019,38(08):3824-3829.   [知网]
  18. 贾恩朝,夏文娇,路臣桂,张会勇,朱武凌*. 人血管内皮生长因子189在毕赤酵母中的表达、纯化及其活性. 中国生物制品学杂志,2017,30(04):346-350.   [知网]
  19. 贾恩朝,朱武凌*. 转化生长因子β Ⅱ型受体在消化系统肿瘤中的研究进展. 重庆医学,2016,45(23):3293-3295+3299.   [知网]
  20. 雷艳杰,孙向东,王春荣,朱武凌*,韩双印*. 可诱导细胞凋亡的FKBP12/caspase-9慢病毒载体的构建与应用. 细胞与分子免疫学杂志,2016,32(01):81-83.   [知网]
  21. 嵇晓辉,张晖,杨金花,朱武凌*. 大鼠肝脏发育成熟及癌变时miR-100的表达. 临床与实验病理学杂志,2015,3:1001-7399.   [知网]   [万方]
  22. 张晖,陈思诺,王仰坤,朱武凌*. 荧光原位杂交法检测肝细胞癌组织中miR-100的表达. 临床与实验病理学杂志,2015,2:1001-7399.   [知网]   [万方]

发明专利

  1. 牛志远, 朱武凌, 郭长江, 支灵通; 抗原结合域自动优化的嵌合抗原受体修饰细胞文库的构建、筛选方法及其应用. 专利号:ZL202110383729.1   [发明专利公布公告]   [SooPAT专利信息]
  2. 郭长江, 陈涵, 牛志远, 支灵通, 朱武凌等; 靶向人膜结合型和可溶性NKG2D配体的嵌合受体、核酸分子、免疫效应细胞及其应用; 专利号:ZL201911358647.0   [发明专利公布公告]   [SooPAT专利信息]
  3. 朱武凌,路臣桂,李明凤,李冬贝,郭长江,张会勇,夏文姣,王晓银,吕探宇. 一种增强型抗肿瘤NK细胞及其制备方法和应用. 专利号:ZL201711297539.8   [发明专利授权公告]   [SooPAT专利检索]
  4. 朱武凌,路臣桂,张会勇,李冬贝,郭长江,李明凤,夏文姣,王晓银,吕探宇. 一种抗肿瘤NK细胞及其制备方法和应用. 专利号:ZL201711298786.X   [发明专利授权公告]   [SooPAT专利检索]
  5. 朱武凌,李明风,王晓银,吕探宇,路臣桂,张会勇,牛志远,郭长江. 一种嵌合共刺激转换受体、编码基因、重组表达载体、抗肿瘤NK细胞及其制备方法、应用. 专利号:ZL201811068231.0   [发明专利授权公告]   [SooPAT专利检索]
  6. 朱武凌,李明风,王晓银,张会勇,路臣桂,吕探宇,陈涵,郭长江,牛志远,支灵通. 一种双靶向转换受体、编码基因、重组表达载体、抗肿瘤NK细胞及其制备方法、应用. 专利号:ZL201811211324.4   [发明专利授权公告]   [SooPAT专利检索]
  7. 张会勇,夏文姣,贾恩朝,闫影,苏静,路臣桂,朱武凌. 靶向VEGF与mucin1的抗肿瘤疫苗、编码基因、表达载体、表达工程菌及应用. 专利号:ZL201610673299.6   [发明专利授权公告]   [SooPAT专利检索]
  8. 张会勇,贾恩朝,路臣桂,胡啸,李源,夏文娇,朱武凌. VEGF165b突变体及其制备方法和应用. 专利号:CN201610216197.1   [发明专利授权公告]   [SooPAT专利检索]

临床试验

  1. NKG2D-CAR-NK92 Cells Immunotherapy for Solid Tumors(NKG2D-CAR-NK92细胞治疗标准治疗失败的晚期转移性实体瘤临床研究)[ClinicalTrials ID: NCT05528341]   [详情]
  2. CCCR-NK92 Cells Immunotherapy for Non-small Cell Lung Carcinoma(CCCR-NK92细胞治疗晚期复发转移多程治疗失败的非小细胞肺癌的临床研究)[ClinicalTrials ID: NCT03656705]   [详情]
  3. NK Cells Treatment for COVID-19[ClinicalTrials ID: NCT04280224]   [详情]